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Thus, it would be a very holy thing and work for Valencia to build a hostel or hospital where such insane or innocent persons could be housed so that they would not be wandering through the city and could not hurt nor be hurt." Pope Sixtus 4th issued a papal bull extending the power of the Inquisition to Spain.

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These things are known in the entire city of Valencia.

, broke out amongst troops in Italy and rapidly spread across Europe, reaching England and Holland in 1496. In 1500 there was an epidemic of syphilis across Europe and in 1505 it reached China.

, Lemnius, Reginald Scotus and Johannes Weyer (1515- 1588).

Typically, this happened at just the moment when other English hospitals were abandoning or cutting back this type of provision severely." ( at York: Pardon to Richard Sharpe of Malteby, for the death of Agnes his wife, as it appears by the record of John de Insula and the others justices of gaol delivery for York, that he was mad when he killed her.

(Calendar of Patent Rolls Reign of , later to become Bethlehem Hospital ("Bedlam"), was taken under the patronage and protection of Richard Lacer, mayor of London, and the citizens of London.

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